Potential Herbs for Management of Polyendocrine Metabolic Ovarian Syndrome and Clinical Studies

Abstract

A common medical illness called Polyendocrine Metabolic Ovarian Syndrome (PMOS) is
characterised by both metabolic and reproductive issues. PMOS is a complex, highly prevalent
endocrine & metabolic disorder. PMOS characterized by hyperandrogenism, ovulatory
dysfunction, and polycystic ovarian morphology. PMOS affects an estimated 10-13% of
reproductive aged women. It is estimated that upto 70% of women is affected with PMOS
worldwide. Although a variety of conventional pharmaceutical interventions are currently used to
manage Polyendocrine Metabolic Ovarian Syndrome (PMOS), their long-term efficacy is often
constrained by poor patient compliance and adverse side effects. Consequently, there has been a
notable surge in patient interest toward complementary and integrative healthcare models.
Historically, traditional medical systems—most notably Traditional Persian Medicine (TPM) and
Traditional Chinese Medicine (TCM)—have heavily relied on botanical therapies to manage
reproductive and gynecological disorders. For centuries, diverse cultures globally have utilized
specific medicinal herbs to alleviate the complex endocrine and metabolic symptoms associated
with PCOS. The aim of this study is to conduct a comprehensive global review of the various
herbal remedies and botanical formulations utilized in the management and therapeutic care of
individuals with PCOS.
Compiling data from multiple clinical and preclinical studies reveals that various botanical
therapies effectively modulate the multifaceted symptoms of PMOS. In particular, evidence
highlights the therapeutic potential of Cinnamomum verum, Trigonella foenum-graecum L., and
Vitex agnus-castus in mitigating metabolic complications such as obesity, impaired insulin
sensitivity, and dyslipidemia. Furthermore, these specific medicinal plants demonstrate a
capacity to restore endocrine balance by downregulating pathways associated with
hyperandrogenism.
To summarize, botanical interventions offer a promising, multi-faceted therapeutic approach to
mitigating the clinical manifestations of PMOS. However, while these natural remedies
demonstrate considerable potential, additional rigorous clinical and laboratory research is
essential to fully elucidate their precise molecular mechanisms, determine standardized dosing
protocols, and confirm their long-term safety profiles.