MICROWAVE ABETTED OPERATIONAL AND ENHANCED SYNTHESIS OF -1,3- THIAZOLIDINE-4-ONE EXPRESSING ANTIMICROBIAL ACTIVITY

Abstract

An efficient, one pot and facile protocol was developed for the series of 2-benzylidene
hydrazinyl-1,3-thiazol-4-(5H)-ones through single pot two stage sequence. Substituted
aromatic aldehydes, thiosemicarbazone, and α-haloesters reacted together in presence of
catalytic iodine to afford new derivatives of thiozolidinones. The strategy works under mild
circumstances and desired products obtained were pure enough without the need of
chromatographic separation. A library of 1,3-thiazolidine-4-one’s so prepared were tested for
their potential regarding antimicrobial activity opposed to S. aureus, E. coli, B. subtilis, as
well as single strain of fungal, Candida albicans. Among different strains studied,
compounds, 3b and 3k found to be potent selectively against Staphylococcus aureus while
compounds, 3d and 3e have shown good activity selectively against Bacillus subtilis.