CONSTITUTIONAL PHENOTYPING OF ACIDUM PHOSPHORICUM IN TYPE 2 DIABETES MELLITUS: A PROSPECTIVE COHORT STUDY : Constitutional Phenotyping of Acidum Phosphoricum in T2DM

Abstract

Type 2 Diabetes Mellitus (T2DM) is influenced by metabolic, neuroendocrine and
psychological factors. This prospective exploratory cohort study developed a structured
constitutional phenotyping model (Total Acidum Phosphoricum Assessment Score, TAPAS)
derived from classical homeopathic literature and explored its association with glycemic
trends. Thirty adults with T2DM were followed for six months. Participants meeting
predefined phenotypic criteria (TAPAS ≥12 with at least two major traits) received adjunctive
Acidum Phosphoricum 30C while continuing stable conventional therapy. Twenty-five
participants qualified for the phenotype. Mean HbA1c decreased from 9.03±0.92% to
7.82±0.96%, with a mean reduction of 1.21% (95% CI 0.87–1.55; p<0.001). TAPAS scores
showed a moderate positive correlation with HbA1c reduction (r=0.46; p=0.01). Exploratory
regression analysis suggested persistence of this association after adjustment for baseline
variables. The findings demonstrate the feasibility of operational constitutional phenotyping
and its measurable association with glycemic trends in T2DM. The results are hypothesis-
generating and support further validation through larger randomized studies.