Aetiopathogenesis and Integrative Therapeutic Modelling of Six Pocket Syndrome: Development of a Neomodel for Holistic Intervention by Bridging Mind, Body, and Sound

Abstract

Background:
Six Pocket Syndrome (SPS) is the suggested sociopsychosomatic construct that is characterised by the multidimensional
dysregulation in the psychological, neurological, endocrine, immunological, metabolic, and behavioural spheres. It is
theorized that chronic psychosocial stress and dysfunctional coping strategies trigger sustained activation of
psychoneuroendocrine axis, which generates systemic desynchronization. Although conceptually similar to stress related
disorders, a single integrative framework that includes mind-body-sound interactions is still lacking.
Objective:
The study will (1) explain the aetiopathogenesis of SPS in terms of psychoneuroendocrine and vibro-acoustic, (2)
determine the effectiveness of an integrative form of therapy involving homoeopathy, psychotherapy, and music therapy,
and (3) create a Neomodel of the holistic approach to intervention, focusing on the restoration of systemic coherence.
Methods:
The quasi-experimental mixed-method design was used with 60 participants (between 25 and 60 years old) with SPS,
who were divided into an intervention (n=30) and control (n=30) group. Individualised homoeopathic prescriptions,
group psychotherapy (CBT and MBSR), and music therapy (auditory entrainment sessions) were provided to the
intervention group during 12 weeks. Outcome measures were psychometric scales (DASS-21, PSS, and BAI) and
physiological indicators (heart rate variability, blood pressure variability), endocrine (serum cortisol, testosterone,
DHEA) and quality of life (WHOQOL-BREF). The statistical analysis was done with SPSS v26.0, and the qualitative
analysis with NVivo v12 using thematic analysis.
Results:
The integrative intervention showed considerable enhancements on psychological, physiological, and endocrine levels.
Cortisol in the serum reduced by 28.9% (p < 0.001), and HRV rose by 33.4% (p < 0.001), showing restoration of the
autonomic balance. Anxiety (reduced by 38.2%), depression (reduced by 46.1%), and perceived stress (reduced by
39.9%) were significantly reduced. Normalization of the endocrine consisted of higher testosterone (↑9.9%) and DHEA
(↑11.5%). Comparisons between-groups showed huge effect sizes (Cohen d > 1.2) in the support of integrative approach.
Qualitative results indicated improved emotional awareness, better sleep, and perceived mind-body-coherence.
Conclusion:
SPS is a multidimensional model of dysregulation induced by stress that is based on psychoneuroendocrine imbalance.
The systematic Neomodel suggested supports the notion that multi-axis modulation of the system using combined
homoeopathic, psychotherapeutic, and music-based techniques is effective in restoring harmony in the system. The
present study is a fundamental guideline to the eventual empirical validity and facilitates the use of multimodal
integrative therapies in the treatment of complex psychosomatic syndromes.