LIPOSOME-BASED DRUG DELIVERY SYSTEMS: FORMULATION, CHARACTERIZATION AND BIOMEDICAL APPLICATIONS

Abstract

Liposomes are small, spherical shaped vesicles made up of phospholipid bilayer surrounding an
aqueous core. Because they are capable of entrapping both hydrophilic and lipophilic substances.
They are naturally compatible with biological system, so they became important part in modern drug
delivery systems. Liposomes are discovered in the 1960s by Alen Behngam and have since
significantly evolved. Scientist have sophisticated in many ways, turning them from simple
laboratory tool to carriers for targeted delivery and nano medicine. This review discusses the
classification, structure and composition of liposomes, methods of preparation, characterization
techniques and various applications across various fields. It also gives an analysis about surface
modification approaches like stimuli-responsive formulations, surface modification approaches to
overcome existing limitations. By combining the fundamental principles with modern development.
This review aims to present a broad point on liposomal technologies and serve as valuable area for
scientists and healthcare professional who involved in development of modern or targeted drug
delivery.