Ayurvedic Prakriti Classification and Its Correlation with Inflammatory Gene Expression Profiles

Abstract

Prakeet Ayurvedic theory of Prakriti means the individual psychophysiological constitution identified
by Vata, Pitta, and Kapha, and is an in-depth explanation of individual variations in disease and health.
The molecular correlates of Prakriti are explored in this study by utilizing the Ayurvedic phenotyping
and the application of contemporary measures of transcriptomic analytics, such as genome-wide
inflammatory gene expression profiles. The study provides the biological insights that can help explain
the natural variation in inflammatory vulnerability and metabolic adjustment through correlating the
different types of Prakriti with variable expression of cytokine regulatory networks, NF- 0B signaling
pathways and immune-modulatory genes. We conclude that Prakriti-specific signature of gene may be
used as biomarkers of customized preventive care and specific Ayurveda-based therapy. It is an
integrative systems biology approach that reconciles the traditional wisdom and modern molecular
science, opening a new individualized paradigm of health prediction and disease modulation based on
the ancient wisdom and the evidence in genomes.