
TY  - JOUR
AU  - NANGWANBIANG KURBAH, 
AU  - SHEENA HAORONGBAM, 
AU  - L. ROBINDRO SINGH, 
AU  - YUMNAM SOMI SINGH, 
AU  - UPASANA DEB, 
PY  - 2026/06/30
Y2  - 2026/09/24
TI  - DEVELOPMENT OF CHITOSAN NANOENCAPSULATED HOUTTUYNIA CORDATA THUNB. EXTRACT: EVALUATING THE EFFECT OF EXTRACT CONCENTRATION-LOAD ON MORPHOLOGY, STRUCTURE AND ANTIOXIDANT ACTIVITY : HOUTTUYNIA CORDATA THUNB. EXTRACT-LOADED CHITOSAN NANOPARTICLES
JF  - The Bioscan
JA  - The Bioscan
VL  - 21
IS  - 2
SE  - Articles
DO  - 
UR  - https://www.thebioscan.com/index.php/pub/article/view/6061
SP  - 21336-21367
AB  - &lt;p&gt;Houttuynia cordata Thunb. extracted in 80% ethanol (HCE) was loaded in chitosan nanoparticles&lt;br&gt;(HCECS) using sodium tripolyphosphate through the ionic gelation method and the resulting HCECS&lt;br&gt;was evaluated for the effect of extract concentration-load on their morphology, structure and antioxidant&lt;br&gt;activity. The encapsulation efficiency (EE) of HCECS nanoparticles was seen to range from 55.5% to&lt;br&gt;86.0%, depending on the extract concentration. Particle size ranged from 331 nm to 409 nm, increasing&lt;br&gt;with increase in extract load, while polydispersity index ranged from 0.176 to 0.212, showing a&lt;br&gt;homogenous particle size distribution. Transmission electron microscopy displayed predominantly&lt;br&gt;spherical nanoparticles. FTIR analysis pointed towards the associations between the functional groups&lt;br&gt;of H. cordata phytochemicals and the chitosan polymer matrix, confirming successful encapsulation.&lt;br&gt;IC50 values of HCE were 135.77μg/ml and 118.28μg/ml for DPPH and ABTS, respectively. For the&lt;br&gt;HCECS nanoparticle, IC50 value of 299.49μg/ml and 149.90μg/ml at the concentration of 5mg/ml HCE&lt;br&gt;for DPPH and ABTS compared to 1mg/ml HCE, 766.08μg/ml and 159.22μg/ml, respectively were&lt;br&gt;observed. For the nanoparticle formulations, antioxidant activity increased as extract loading increased.&lt;br&gt;The results indicate that there is effect of HCE loading in the formulation of chitosan nanoparticles as&lt;br&gt;well as on the antioxidant activity, which highlights the importance of creating a balance between&lt;br&gt;encapsulation efficiency and antioxidant activity during nanoparticle development for H. cordata.&lt;/p&gt;
ER  -